I ran into an issue with Windows 10 and the Arduino IDE 18.104.22.168 when trying to program the Intel Curie 101 just using the normal "Blink" example after loading the required Intel Curie 101 via the boards manager. Arduino: 1.8.2 (Windows Store 22.214.171.124) (Windows 10), Board: "Arduino/Genuino 101" fork/exec C:\Users\UDOO\Documents\ArduinoData\packages\Intel\tools\arc-elf32\1.6.9+1.0.1/bin/arc-elf32-g++.exe: An error in a system binary was detected. Try refreshing the PC to fix the problem. Error compiling for board Arduino/Genuino 101. This report would have more information with "Show verbose output during compilation" option enabled in File -> Preferences. Googling the error message, I'm not alone with this error, however, trying the workaround by setting the security setting per this thread did not resolve. https://github.com/01org/corelibs-arduino101/issues/309 That said, the easier workaround was to just go browser based All Arduino and Genuino boards, including this one, work out-of-the-box on the Arduino Web Editor, no need to install anything. The Arduino Web Editor is hosted online, therefore it will always be up-to-date with the latest features and support for all boards. Follow this simple guide to start coding on the browser and upload your sketches onto your board.